WebDeferoxamine mesylate is an iron chelator. Also hypoxia mimetic and inhibitor of ferroptosis. Has neuroprotective effects in animal models of stroke, traumatic brain injury and neurodegenerative diseases. Technical Data. M.Wt: 656.79. Formula: C 25 H 48 N 6 O 8.CH 4 O 3 S. Solubility: Soluble to 100 mM in water. Storage: WebDeferoxamine. Deferoxamine (DFO) is an iron chelator that decreases FR production by binding with iron and decreasing the production of OH− that occurs via the Fenton reaction, while also stabilizing HIF-1α to produce its downstream products VEGF and EPO (Hamrick et al, 2005; Mu et al, 2005). From: Avery's Diseases of the Newborn (Ninth ...
Deferoxamine: Uses, Interactions, Mechanism of Action - DrugBank
WebThese effects were all blocked by the endolysosome-specific iron chelator deferoxamine (DFO). Thus, the endolysosome de-acidification-induced release of endolysosome Fe2+ … WebJan 26, 2024 · Alternate Names: Deferoxamine mesylate is also known as DFOM. Application: Deferoxamine mesylate is a bacterial siderophore, an iron chelator which induces apoptosis and is used to experimentally inhibit iron-dependent prolyl hydoxylases. CAS Number: 138-14-7. Purity: ≥94%. Molecular Weight: 656.79. ordering additional death certificates
deferoxamine mesylate for injection, USP Dosage and …
WebDesferal, deferoxamine mesylate USP, is an iron-chelating agent, available in vials for intramuscular, subcutaneous, and intravenous administration. Desferal is supplied as … WebDec 10, 2009 · The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke … Deferoxamine mesylate for injection, USP, is an iron-chelating agent, available in vials for intramuscular, subcutaneous, and intravenous administration. Deferoxamine mesylate is supplied as vials containing 500 mg and 2 g of Deferoxamine mesylate USP in sterile, lyophilized form. … See more Deferoxamine mesylate chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions. It readily chelates iron from ferritin and … See more Deferoxamine mesylate for injection, USP, is indicated for the treatment of acute iron intoxication and of chronic iron overload due to transfusion-dependent anemias. Acute Iron Intoxication Deferoxamine mesylate is an … See more Ocular and auditory disturbances have been reported when Deferoxamine mesylate was administered over prolonged periods of time, at high doses, or in patients with low ferritin levels. The ocular disturbances … See more Known hypersensitivity to the active substance. Deferoxamine mesylate is contraindicated in patients with severe renal disease or anuria, since the drug and the iron chelate are … See more ordering acai bowls