Erythronolide synthase
WebNational Center for Biotechnology Information WebMar 17, 2024 · A strategy for an enantiospecific total synthesis of erythronolide B evolved from the recognition that the C2-4 and C10-12 segments are identically substituted but …
Erythronolide synthase
Did you know?
WebJan 23, 2007 · Erythronolide synthase is composed of EryAI, EryAII and EryAIII multimodular (2 modules) polypeptides each coding for a functional synthase subunit which participates in 2 of the six FAS-like elongation steps required for formation of the polyketide. Module 1, 2, 3, 4, 5, and 6 participating in biosynthesis steps 1, 2, 3, 4, 5, and 6, … WebThe antibiotic erythromycin is a complex polyketide of a 14-membered lactone called erythronolide B, which is connected to two deoxysugars called l-mycarose and d …
Web8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. … WebMar 17, 2024 · Erythronolide B from Sugar-derived Homochiral Building Blocks. A strategy for an enantiospecific total synthesis of erythronolide B evolved from the recognition that the C2-4 and C10-12 segments are identically substituted but have different absolute stereochemistries.
WebNov 24, 2010 · The collective polyketide synthase is referred to as deoxyerythronolide B synthase (DEBS) and is composed of the DEBS1, 2, and 3 enzymes (Figure 1 B). Furthermore, the system requires (2S)-methylmalonyl-CoA and propionyl-CoA substrates that may prompt separate metabolic engineering of the heterologous host to support … Websynthase, β-ketoacyl reductase, β-ketoacyl dehydratase enzyme-bound 6-deoxy-erythronolide seco acid (linear heptaketide) cyclization upon cleavage from polyketide …
WebErythronolide synthase proteins 1, 2 and 3 from Saccharopolyspora erythraea which is involved in the biosynthesis of the polyketide antibiotic erythromicin. Each of these proteins contains two CP domains. Conidial green pigment synthase from Aspergillus nidulans. ACV synthase from various fungi.
WebOne of the BLASTp hits of an intestine-derived type I PKS contigs from the symbiotic microbiome of the mangrove shipworm Neoteredo reynei is an erythronolide synthase [53]. ... helios russiahelios ray vesselIn enzymology, an erythronolide synthase (also 6-Deoxyerythronolide B Synthase or DEBS) is an enzyme that catalyzes the chemical reaction 6 malonyl-CoA + propanoyl-CoA $${\displaystyle \rightleftharpoons }$$ 7 CoA + 6-deoxyerythronolide BThus, the two substrates of this enzyme are malonyl-CoA and propanoyl … See more Essential components Ketosynthase The active site of this enzyme has a very broad specificity, which allows for the synthesis of long chains of carbon atoms by joining, via a See more Since the late 1980s and early 1990s research on polyketide synthases (PKS), a number of strategies for the genetic modification of such PKS have been developed and … See more • Omura S, Nakagawa A (1981). "Biosynthesis of 16-membered macrolide antibiotics". Antibiotics. 4: 175–192. doi:10.1007/978-3-642-67724-3_8. ISBN 978-3-642-67726-7 See more Fatty acid synthesis in most prokaryotes occurs by a type II synthase made of many enzymes located in the cytoplasm that can be separated. However, some bacteria such as Mycobacterium smegmatis as well as mammals and yeast use a type I synthase which is a … See more As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1KEZ, 1MO2, 1PZQ, 1PZR, 2HG4, 2JU1, 2JU2, and 2QO3. Other names of this … See more helios photovoltaic sdn bhdWebErythronolide synthase. NCBI. National Center for Biotechnology Information. Search. 1PZQ: Structure of fused docking domains from the erythromycin polyketide synthase … helios sailor moon wikiWebdemethoxycurcumin synthase activity from feruloylacetyl-CoA diacylglycerol transacylase activity dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity erythronolide synthase activity fatty acid synthase activity + fatty-acyl- [acp] elongase/decarboxylase activity flavonol-3-O-triglucoside O-coumaroyltransferase activity helios saleWebErythronolide synthase Erythronolide synthase. Dietmar Schomburg 2 & Dörte Stephan 2 Chapter; 11 ... helios sailor moonWebMar 1, 1994 · 6-deoxyerythronolide-B synthase. Alternative Name(s) 6-deoxyerythronolide B synthase. DEBS. deoxyerythronolide B synthase. erythronolide-condensing enzyme. … helios silver