Lactate chemoresistance
WebOct 1, 2024 · Lactate is a pleiotropic signalling molecule capable of regulating several biological processes, including immune–inflammatory responses, angiogenesis, and fibrosis. ... [28], favouring chemoresistance. Chemoresistance is also increased by GPR81-dependent increased expression and activity of the drug-exporting transporter ABCB1, … WebCurcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1. Curcumin has been demonstrated to …
Lactate chemoresistance
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WebSep 19, 2024 · Therefore, it is believed that targeting the aspects of glucose metabolism mentioned above could lead to novel therapeutic options. More specifically myeloma cells mainly enhance glycolysis and lactate production instead of TCA cycle activation. This results in tumor growth, myeloma survival and, finally, chemoresistance. WebMar 4, 2024 · Lactate concentration was determined with a Lactate Assay Kit (Millipore SIGMA) following the manufacturer's instruction. Measurement of Energy Metabolism in Cells A549 lung cancer cells were seeded in the lower chamber, and M2 macrophages were seeded in transwell inserts.
WebApr 29, 2024 · Chemoresistance, both acquired and primary, is proven to be associated with complex multifactorial processes such as increased drug efflux, reduced drug uptake, … WebLactate affects the immunometabolic mechanism of chemoresistance in CRC Schematic illustration showing mechanisms of action associated with targeting lactate metabolic reprogramming to reverse ...
WebOct 19, 2024 · Soni and colleagues showed lactate-induced chemoresistance against doxorubicin along with upregulation of HCA1 protein and increased expression of the … WebOct 23, 2024 · The high levels of lactate accumulation in tumor microenvironment has been associated with certain key features of tumor progression including senescence …
WebFeb 6, 2024 · In aerobic glycolysis, glucose is processed into lactate even in the presence of oxygen, providing ATP and building blocks very quickly to support tumor cell survival and proliferation [81,82]. ... MiR-21 mediates chemoresistance by acting in BC cells and TAM recruitment. In BC cells, miR-21 promotes survival by targeting PTEN and PDCD.
WebMay 20, 2024 · Several cellular processes are regarded as key mechanisms underlying chemoresistance, including drug activation or inactivation, repair machinery of DNA damage, modifications in drug targets, inactivation of apoptotic pathways, and increased autophagy [ … the bad trapWebApr 13, 2024 · N6-methyladenosine (m6A) is the most abundant modification of eukaryotic mRNA and is involved in almost every stage of RNA metabolism. The m6A modification on RNA has been demonstrated to be a regulator of the occurrence and development of a substantial number of diseases, especially cancers. Increasing evidence has shown that … the greenies pdfWebOct 19, 2024 · lactate and lactate intrinsic activity as an HDAC inhibitor in the development of an anticancer therapy-resistant tumor phenotype, with special focus on cervical cancer … the green imageWebOct 19, 2024 · Lactate drives cellular DNA repair capacity: Role of lactate and related short-chain fatty acids in cervical cancer chemoresistance and viral infection the bad twin 2016WebMay 20, 2024 · Lactate dehydrogenase A (LDHA) and pyruvate dehydrogenase kinases (PDKs) are known as key regulators of aerobic glycolysis producing lactate from pyruvate … the greenimalistWebIn 2010, we published a collaborative study with Michael Baumann’sgrouponradioresistanceinalargecohortofhumanheadandneckcancerxenografts (Sattleretal.2010),followingstandardclinicalprotocolsforirradiationdoseandfractionation scheme.Unlikemanymetabolicparametersinvestigated,lactateconcentrationwasadominant … the green im coming home lyricsWebChemoresistance is one of the main causes of poor prognosis in GC. In the 97 GC cases collected in SYSUFAH, we further performed a subgroup analysis of patients who underwent tegafur gimeracil oteracil potassium capsule (S‐1) plus oxaliplatin (SOX regimen) after surgery. ... Lactate is significantly elevated in many tumors, 29 and an elevated ... the green iguana tampa