List of lysosomotropic agents
Web16 mrt. 2024 · The purpose of these studies was to characterize the cellular impact of lysosomotropic compounds. As shown in Table 1, eight therapeutically and structurally diverse drugs, including chloroquine, fluoxetine, imipramine, dimebon, tamoxifen, chloropromazine, amitriptyline, and verapamil were selected. Web14 feb. 2013 · Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363 Francois Lamoureux; Christian Thomas; Claire Crafter; Masafumi Kumano; Fan Zhang; Barry R. Davies; Martin E. Gleave; Amina Zoubeidi Author & Article Information Clin Cancer Res (2013) 19 (4): 833–844.
List of lysosomotropic agents
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Web9 sep. 2024 · May 2024 · Methods in molecular biology (Clifton, N.J.) Tomoki Kuwahara. Leucine-rich repeat kinase 2 (LRRK2) is a causative gene product of autosomal-dominant Parkinson’s disease and has been ... Web19 okt. 2024 · Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting lower cancer incidence in individuals receiving long term drug treatment.Experimental …
Web22 nov. 2013 · It is well documented that lysosomotropic agents can trigger lysosomal membrane permeabilization [52,53]. We have previously shown that the cell death associated with lysosomotropic compounds can be rescued by Bafilomycin A, which increases lysosomal pH and prevents compound accumulation, further supporting … WebWidely Available Lysosomotropic Agents Should Be Considered as a Potential Therapy for COVID-19 Jan Homolak * and Ivan Kodvanj Version 1 : Received: 21 March 2024 / …
Web1 aug. 2024 · Some lysosomotropic compounds used in experimental work on endolysosomal trafficking and function include the tricyclic antidepressants, imipramine and amitriptyline; the antipsychotic, chlorpromazine; and the selective serotonin re-uptake inhibitor, fluoxetine [50]. WebLysosomotropic agents include kinase inhibitors such as ML-9, 179 metal nanoparticles (NPs), 180 and some pharmaceutically important drugs, which include nortriptyline, siramesine, desipramine, clomipramine, imipramine, etc. 48 The chemical structure of some of these compounds is listed in Figure 4.
Web1 okt. 2024 · 1. Antiviral effects of highly accumulating lysosomotropic drugs. Currently available antiviral drugs were mainly designed to target a specific viral or human protein crucial for infection with a specific type of virus [1].Considering the diversity and constant mutations of viruses, it will not come as a surprise if these antiviral drugs are shown to be …
Web20 mrt. 2024 · Widely Available Lysosome Targeting Agents Should Be Considered as a Potential Therapy for COVID-19 Authors: Jan Homolak University of Zagreb Ivan Kodvanj University of Zagreb Abstract and... tamil plural wordsWeb15 sep. 1974 · Lysosomotropic agents ChristianDe Duveab ThierryDe Barsyab† BrianPooleab Andre´Trouetab‡ PaulTulkensab§ Fran¸oisVan Hoofab¶ Show more Add … tamil population in canadaWebLysosomal exocytosis is also perturbed in a variety of lysosomal and lipid storage disorders (reviewed in Samie and Xu, 2014;Settembre and Ballabio, 2014), and lysosomal exocytosis can drive the... tamil pleasent songsWebSome of these drugs -particularly azithromycin and other macrolides, indomethacin and some other non-steroidal anti-inflammatory drugs, proton pump inhibitors and … tamil pocket newsWeb10 mrt. 2024 · Pharmaceutical lysosomotropic agents include the antidepressants siramesine, nortriptyline, desipramine, imipramine, and clomipramine [ 19 ]. These have shown effectiveness in breast cancer, colon cancer, and CLL cells. Antimalarials mefloquine and chloroquine have shown effectiveness in breast cancer, lymphoma, and leukemia … tamil playback singersWebMany drugs approved for clinical medicine are lysosomotropic agents, characterized by promoting particular effects including cytoplasmic vacuolization, increase in number … tamil population in australiaWeb9 feb. 2024 · Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a major issue for people living with cancer and their providers. A diverse set of cellular and inter-organellar signaling changes have been implicated in chemoresistance, but it is still unclear what processes lead to chemoresistance and … tamil pop songs download