Druglikeness is a qualitative concept used in drug design for how "druglike" a substance is with respect to factors like bioavailability. It is estimated from the molecular structure before the substance is even synthesized and tested. A druglike molecule has properties such as: • Solubility in both water and fat, as an orally administered drug needs to pass through the intestinal lining after it is consumed, be carried in aqueous blood and penetrate the lipid-based c… WebMolar refractivity, [1], is a measure of the total polarizability of a mole of a substance and is dependent on the temperature, the index of refraction, and the pressure. where is the Avogadro constant and is the mean polarizability of a molecule. Substituting the molar refractivity into the Lorentz-Lorenz formula gives, for gasses.
Molar Refractivity (MR)
WebMolar refractivity, A, is a measure of the total polarizability of a mole of a substance and is dependent on the temperature, the index of refraction, and the pressure. The molar refractivity is defined as shown. Related formulas. Variables. A: … http://scfbio-iitd.res.in/software/drugdesign/lipinski.jsp miche bag shell covers
Pharmacokinetics and drug-likeness of antidiabetic flavonoids
Web10 dec. 2024 · Physicochemical property, drug likeness, and pharmacokinetic predictions. Pharmaceutically significant descriptors and physically relevant properties of the target flavonoids were predicted [45, 46].The physicochemical properties (molar refractivity, topological polar surface area, number of hydrogen bond donors/number of hydrogen … WebJoo Y, Kim HS, Woo RS, Park CH, Shin KY, Lee JP, Chang KA, Kim S, Suh YH: Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models. Mol Pharmacol. 2006 Jan;69(1):76-84. Epub 2005 Oct 13. [PubMed:16223958 ] WebA quantitative characterization based on computed physicochemical property profiles such as log P, molar refractivity, molecular weight, and number of atoms as well as a qualitative characterization based on the occurrence of functional groups and important substructures are developed here. miche bags amazon