Phis-peg
WebbFinally, PEG-Phis copolymers were synthesized by deprotecting the DNP group of PEG-Phis-DNP with 2-mercaptoethanol. The structure of PEG-Phis was confirmed by using 1 H nuclear magnetic resonance spectroscopy (1 H-NMR, Supplementary Material: Figure S2) (400MHz, DMSO-d 6). WebbPreparation of M-NP-Gnb nanomicelles The pHis-PEG was synthesized by a ring opening polymerization process. Poly(L-histidine) was conjugated with PEG via an amide bond.In the case of PLGA-PEG-NH 2, PEG-diamine was reacted with PLGA-NHS and the resulting product was reacted with mannose.The mannosylation was performed by ring opening …
Phis-peg
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WebbMoreover, PHis-based nanocarriers achieved endo-somal escape in acidic subcellular compartments such as endosomes through proton sponge effect. PHis-based nanocarriers have thus great potential as an acid triggering tumor-killing platform [25–28]. For example, Bae et al. described that pH-sensitive PHis-PEG/PLLA-PEG mixed micelles were ... Webb14 apr. 2015 · A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the …
Webb16 aug. 2024 · The pH sensitivity was confirmed by changes in particle size, critical micelle concentration, and transmittance as a function of pH. MTT assay showed that … Webb22 nov. 2024 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and privacy notice and
WebbImpact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines - Nature Reviews Immunology Liked by Thiruganesh Ramasamy, M.Pharm, Ph.D. Congratulations Eric on publication of such impacting idea. WebbHerein, we design a simple strategy to fabricate poly (ethylene glycol) (PEG)-modified one-dimensional nanoscale coordination polymers (1D-NCPs) with intrinsic biodegradability, …
WebbThe PHIS-PEG 2000 was synthesized via a reaction between the amine group of the PHIS 3000 and the NHS group of the mPEG 2000 -NHS. ... View in full-text Context 2
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